The Boston Globe

Cystic fibrosis drug Trikafta helps most but not all with the deadly genetic disease

Cystic fibrosis miracle drug Trikafta, helps 90% of people, the other 10% are still waiting for their aid. (Randy Vazquez/Globe Staff) ( Randy Vazquez )

A breakthrough cystic fibrosis drug gave them the gift of time. But miracles come with complications.

With Vertex's cystic fibrosis drug Trikafta, death no longer looms so close for many patients. But now, they face unfamiliar worries about careers, money, and old age — “the existential threat of living.”

Boston Globe Today

Watch: Reporter Felice Freyer explains how Trikafta changes everything for some CF patients

When a new drug for cystic fibrosis was approved in 2019, it was a true miracle treatment for thousands of patients. But it also raised some new existential questions for them.

Buddy Teevens, winningest football coach in Dartmouth history and gridiron innovator, dies at 66
He won five Ivy League championships with the Big Green but more importantly was responsible for advances in player safety.

Why has Massachusetts become a hot spot for Power Five schools to recruit quarterbacks?
Five quarterbacks with Bay State connections have committed to big-time football schools, and they say they helped each other get there.

Globe Summit 2023

At Globe Summit, local college presidents speak out on the future of higher education

At an event moderated by Linda Henry, CEO of Boston Globe Media, the leaders of three Boston-area schools said they are confronting changing consumer demands, enrollment declines, and public distrust in higher education — challenges that require adept leadership and innovation.

See the full schedule for Globe Summit 2023

DINING OUT | ★★★★

At Lenox Sophia, every night is a dinner party

The BYO South Boston restaurant is where fine dining comes to relax.

The Biden administration finally named a coordinator to combat book bans. That was the easy part.

Even as they see a political opportunity to take on the conservative “parents’ rights” movement, the options for the federal government to engage are limited and themselves politically fraught.

Workers say Red Line train ignored a warning and blew by them at 25 mph on Monday, according to report

The incident, along with another near miss reported this week, raise the prospect of more mandates from federal regulators that could further limit the T’s ability to repair its tracks, delaying fixes to speed a system riddled with slow zones.

Witness: Man fatally injured at Gillette was punched twice in head by man in Miami Dolphins jersey
Joey Kilmartin said that after Dale Mooney was punched, he fell backward and did not move even when first responders arrived and provided first aid, including the use of a defibrillator.

Woman sentenced to probation for racial incident involving Muslim Melrose city councilor
Joan Ditomaso, 68, of Melrose, was also ordered to stay away from City Councilor Maya Jamaleddine, her husband and their children, who witnessed the confrontation on Dec. 3 when Ditomaso verbally accosted Jamaleddine and shoved her husband.

Lawmakers want ‘hard numbers’ on state’s shelter crisis after Healey’s request for $250 million

House Speaker Ronald Mariano said Tuesday that he was not sure if his chamber would support the $250 million request, which Healey folded into a wider spending bill last week.

MCAS scores are still well below pre-pandemic levels

The state's high-schoolers recorded no gains on the state exam versus the prior year, despite over a billion dollars in federal pandemic relief money spent.

These 66 Massachusetts schools were recognized by the state for strong performance See 2023 MCAS scores for schools across the state

Hispanic Heritage Month

Performers with Aqua Sol Serano, from Hyde Square Task Force Youth in Action, danced to the sounds of Jorge Arce and his musicians. To celebrate the start of Latinx Heritage Month, a Fiesta en la Plaza was held on Boston’s City Hall Plaza.

Latinx Heritage Month kicks off with fiesta on City Hall Plaza

Veronica Robles (center), a Boston-based Mariachi singer, with Cassandra McDonald (left) and Nicole Edgecomb (right), is slated to perform at the City of Boston’s Fiesta en la Plaza.

How to celebrate Hispanic Heritage Month in Boston

My night at Havana Club, the heart of salsa and bachata dancing in Cambridge

Four girls at an athletic field in Roxbury, at a recreational sporting event sponsored by La Alianza Hispana.

IDEAS | OMAR VEGA

Rarely seen snapshots of Latino Boston

Bobby Dalbec lost weight over the course of the season to improve his athleticism and his power did not suffer.

Peter Abraham | RANGERS 6, RED SOX 4

Bobby Dalbec, 28, is not the same player who was cut at the end of spring training by the Red Sox

Dalbec, in his eighth season in pro ball, said he is really figuring it out.

Commuters wearing face masks walk along a pedestrian bridge during the evening rush hour in Beijing earlier this year.

Northeastern among sites chosen by CDC to establish ‘National Weather Service’ for infectious disease

The CDC has given Northeastern University $17.5 million to establish a center to forecast infectious disease outbreaks.

Marcus Smart celebrated his wedding over the weekend with a few of his former Celtics teammates.

Marcus Smart’s wedding turned into a Celtics reunion featuring Jayson Tatum, Brad Stevens, and more

Smart celebrated his wedding day alongside his wife, Maisa Hallum, on Saturday.

Opinion

In cases involving domestic violence, DCF’s first obligation is to protect the child. But there are options that do not punish the parent who survived domestic violence.

EDITORIAL

Don’t blame domestic violence victims in child welfare cases

DCF should be guided by best practices.

IDEAS | MELANIE BROOKS

A daughter who couldn’t ask questions is now a mother who invites them

JEFF JACOBY

Live long and prosper

SCOT LEHIGH

There they go again: Trump and his enablers spread another large lie

RENÉE GRAHAM

So many celebrity apologies, so little sincerity

Experience Globe Summit September 19-21
Watch for free here

Who was Peter Faneuil? A Bostonian, merchant, philanthropist — and slave trader.
Most Bostonians know little about the man for whom Faneuil Hall is named, who enriched himself by trafficking in human beings. Should knowing that history change the way the city remembers him?

Share your thoughts on Peter Faneuil: Merchant prince, philanthropist, slave trader

Peter Faneuil was an active trafficker who financed voyages from Boston to West Africa to purchase hundreds of slaves. And he kept at least five slaves to serve his own household.

Watch | Boston Globe Today: How and why we compiled the history of Peter Faneuil

More recent News

Missing autistic boy from Chelsea found safe at Cambridge recreation center

Susant Thapa, 11, was located shortly after 7 p.m. Tuesday at an indoor pool facility adjacent to Cambridge Rindge and Latin School, Chelsea police said. Police had said the boy, who is nonverbal, was drawn to swimming pools and had asked the public to check them.

Voters pick 2 finalists for mayoral race in Manchester, N.H.
Jay Ruais and Kevin Cavanaugh will face off in the Nov. 7 general election to determine who will lead the largest city in northern New England.

Mass. approves new health and sex ed guidelines for the first time since 1999
The state first started the process of revising sex ed curriculum standards in 2018, and approved the new framework Tuesday after soliciting public comment over the summer.

Boston NWSL team sees this as ‘right moment, right city’ for women’s pro soccer reboot
A hopeful note was sounded as Boston was officially introduced as an expansion franchise in the current 12-team league.

‘Sky is the limit’: Tom Brady explains why he mentors Deion Sanders’s son Shedeur
"I'm always here for him," Brady said. "Because in him I see someone who has a great work ethic, but wants the knowledge too."

Eastern Bank will acquire Cambridge Trust, and sell its insurance division
The move will beef up the Boston-based bank’s wealth management operation while divesting its slower-growing insurance business.

Some N.H. residents are balking at an ordinance requiring them to cut their lawns

Receiving the notice made Jacqui Pierce even more determined to convert her lawn into an oasis for pollinators.

Mow-no-more? How to make a pollinator-friendly yard.

Celebrating its 400th anniversary, the leading name in crashing, banging, and clanging has made a home here
Cymbal-maker Zildjian, described as the oldest family-run business in America, was founded in Turkey in 1623 but now makes its home in Norwell. On Wednesday, it's planning quite a bash to mark its milestone.

Joe’s Pizza, a New York classic, is now open in Harvard Square until 3 a.m.
Who said local nightlife was dead?

In bid to stop Trump, one group is making different pitch to independents and Democrats: Vote GOP
With a largely drama-less Democratic presidential field, a new super PAC is trying to persuade independent voters in New England — and beyond — to vote in the GOP primary.

Culture & Lifestyle

Books podcasts to help you feel like you've joined your favorite book club.

10 podcasts that will make you feel like you’re in a book club

Janelle Monáe performs at MGM Music Hall at Fenway Sunday night.

At MGM Music Hall, a Janelle Monáe joy ride

How to celebrate Hispanic Heritage Month in Boston

Butterfly (Karen Chia-ling Ho, center) is a nightclub entertainer in BLO's new production of "Madama Butterfly."

‘Madama Butterfly’ is a poignant American tragedy at Boston Lyric Opera

Special Projects

Boston thrives off the dreams of young people. But can they make it here?

Baby boomers and Gen Xers benefited from economic conditions that do not exist for millennials. And by many measures, the path ahead for Gen Z is even more fraught.

Boston, MA—12/14/2022 - Commuters wait for the T to arrive at Ruggles Station. (Jessica Rinaldi/Globe Staff)

Boston doesn’t work if the T doesn’t work

With the MBTA engulfed by issues, everyday riders are feeling the pain.

Brittany Tee, Soomaiiah Quraiishi, and Reina Morales Rojas are among thousands of people thought to be missing from Massachusetts.

How the missing become the uncounted

Inside the government’s flawed approach to finding missing persons.

Two Weeks in America

We sent a dozen journalists on the road across this complex country. They found it’s better than you think.

FROM OUR PARTNERS

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Opinion, ideas, and commentary

Astrida Schaeffer received an infusion of Leqembi at Brigham and Women’s Hospital on Aug. 15.

Hampus Hillerstrom and Jo Ann Simons

People with Down syndrome deserve access to Alzheimer’s treatment

During a Sept. 11 campaign event in Rye, N.H., Chris Christie, a Republican presidential primary candidate, autographed a photo of him with Barack Obama.

Carine Hajjar

Chris Christie takes on mission impossible in GOP presidential nomination race

A cyclist sloshed through Coolidge Corner.

EDITORIAL

When building bike lanes isn’t enough

The upper shelves at Bear Pond Books in Montpelier, Vt., were spared by the flood waters that laid waste to downtown in July.

IDEAS | BRYAN PFEIFFER

After the Vermont flood

Army veteran Bob Perry entered a polling precinct to cast a ballot in the Massachusetts presidential primaries in 2020 in Seekonk.

JOAN VENNOCHI

Keep Trump on the ballot and let voters decide

"This city is special," the author writes, "and Boston, so restrained in emotion, deserves to hear this more often."

IDEAS | OMER AZIZ

My farewell love letter to Boston

Metro

Cystic fibrosis drug Trikafta helps most but not all with the deadly genetic disease

“Waiting for Hope, Fighting for Tomorrow” explores the lives of people at opposite ends of the spectrum: those who are benefiting from the drug and those still waiting for their “miracle drug.”

BUSINESS

‘Permanent’ jewelry is ‘kind of like part of you’ (yes, you can change your mind)

Erin Myles opened Brave Daughters in Providence in 2018, and a popup location in Boston in 2022.

A breakthrough cystic fibrosis drug gave them the gift of time. But miracles come with complications.

Cystic fibrosis drug Trikafta helps most but not all with the deadly genetic disease

Cystic fibrosis miracle drug Trikafta, helps 90% of people, the other 10% are still waiting for their aid. (Randy Vazquez/Globe Staff)

Sports

Tennis legend Billie Jean King speaks during the opening ceremony of the of the US Open, Aug. 28, in New York.

On 50th anniversary of Billie Jean King’s ‘Battle of the Sexes’ win, a push to honor her in Congress

Billie Jean King’s victory in the “Battle of the Sexes” was a milestone moment as women pushed for equality on the playing field and beyond.

Standout Xaverian quarterback Henry Hasselbeck has committed to Michigan State.

High School Football

Why has Massachusetts become a hot spot for Power Five schools to recruit quarterbacks?

Five quarterbacks with Bay State connections have committed to big-time football schools, and they say they helped each other get there.

patriots

Trent Brown, Patriots reportedly agree to revised contract with $2 million added in incentives

Brown and the Patriots have agreed to a revised contract that will see the team add another $2 million in potential incentives this season, per ESPN.

celtics

Paul Pierce explains how he joined Jayson Tatum’s ‘support system’ during summer workouts

rangers 6, red sox 4

Another uneven night for Tanner Houck and the bullpen costs Red Sox against the Rangers

Peter Abraham | On baseball

Bobby Dalbec, 28, is not the same player who was cut at the end of spring training by the Red Sox

Business

BUSINESS

‘Permanent’ jewelry is ‘kind of like part of you’ (yes, you can change your mind)

Erin Myles opened Brave Daughters in Providence in 2018, and a popup location in Boston in 2022.

A breakthrough cystic fibrosis drug gave them the gift of time. But miracles come with complications.

Speaker McCarthy faces an almost impossible task trying to unite House GOP and fund the government

Homeowners face rising insurance rates as climate change makes wildfires, storms more common

magazine

Jorge Arroyo behind the scenes at the Booth Theatre at Boston University.

My Boston History

Shining a spotlight on the lack of diversity backstage

From left: Constanza Cabello, Elias Torres, Amanda M. Fernández, Jay Calderín, Silvia López Chavez, and Dr. Daniela RamÍrez Schrempp

Marcela García

Meet six Mass. leaders from Amplify LatinX's ALX100 list

Head to Boston Landing this Saturday for a free event to celebrate the season.

Your Week Ahead

Five things to do around Boston, Sept. 18-24

This week's daters: Ryan L. and Emily K.

Dinner with Cupid

A breakthrough cystic fibrosis drug gave them the gift of time. But miracles come with complications.

Watch: Reporter Felice Freyer explains how Trikafta changes everything for some CF patients

Buddy Teevens, winningest football coach in Dartmouth history and gridiron innovator, dies at 66 He won five Ivy League championships with the Big Green but more importantly was responsible for advances in player safety.

Why has Massachusetts become a hot spot for Power Five schools to recruit quarterbacks? Five quarterbacks with Bay State connections have committed to big-time football schools, and they say they helped each other get there.

At Globe Summit, local college presidents speak out on the future of higher education

At Lenox Sophia, every night is a dinner party

The Biden administration finally named a coordinator to combat book bans. That was the easy part.

Workers say Red Line train ignored a warning and blew by them at 25 mph on Monday, according to report

Witness: Man fatally injured at Gillette was punched twice in head by man in Miami Dolphins jersey Joey Kilmartin said that after Dale Mooney was punched, he fell backward and did not move even when first responders arrived and provided first aid, including the use of a defibrillator.

Lawmakers want ‘hard numbers’ on state’s shelter crisis after Healey’s request for $250 million

MCAS scores are still well below pre-pandemic levels

Latinx Heritage Month kicks off with fiesta on City Hall Plaza

How to celebrate Hispanic Heritage Month in Boston

My night at Havana Club, the heart of salsa and bachata dancing in Cambridge

Rarely seen snapshots of Latino Boston

Bobby Dalbec, 28, is not the same player who was cut at the end of spring training by the Red Sox

Northeastern among sites chosen by CDC to establish ‘National Weather Service’ for infectious disease

Marcus Smart’s wedding turned into a Celtics reunion featuring Jayson Tatum, Brad Stevens, and more

Don’t blame domestic violence victims in child welfare cases

A daughter who couldn’t ask questions is now a mother who invites them

Live long and prosper

There they go again: Trump and his enablers spread another large lie

So many celebrity apologies, so little sincerity

Who was Peter Faneuil? A Bostonian, merchant, philanthropist — and slave trader. Most Bostonians know little about the man for whom Faneuil Hall is named, who enriched himself by trafficking in human beings. Should knowing that history change the way the city remembers him?

Share your thoughts on Peter Faneuil: Merchant prince, philanthropist, slave trader

More recent News

Missing autistic boy from Chelsea found safe at Cambridge recreation center

Voters pick 2 finalists for mayoral race in Manchester, N.H. Jay Ruais and Kevin Cavanaugh will face off in the Nov. 7 general election to determine who will lead the largest city in northern New England.

Mass. approves new health and sex ed guidelines for the first time since 1999 The state first started the process of revising sex ed curriculum standards in 2018, and approved the new framework Tuesday after soliciting public comment over the summer.

Boston NWSL team sees this as ‘right moment, right city’ for women’s pro soccer reboot A hopeful note was sounded as Boston was officially introduced as an expansion franchise in the current 12-team league.

‘Sky is the limit’: Tom Brady explains why he mentors Deion Sanders’s son Shedeur "I'm always here for him," Brady said. "Because in him I see someone who has a great work ethic, but wants the knowledge too."

Eastern Bank will acquire Cambridge Trust, and sell its insurance division The move will beef up the Boston-based bank’s wealth management operation while divesting its slower-growing insurance business.

Recommended reads

Some N.H. residents are balking at an ordinance requiring them to cut their lawns

Joe’s Pizza, a New York classic, is now open in Harvard Square until 3 a.m. Who said local nightlife was dead?

In bid to stop Trump, one group is making different pitch to independents and Democrats: Vote GOP With a largely drama-less Democratic presidential field, a new super PAC is trying to persuade independent voters in New England — and beyond — to vote in the GOP primary.

Culture & Lifestyle

10 podcasts that will make you feel like you’re in a book club

At MGM Music Hall, a Janelle Monáe joy ride

How to celebrate Hispanic Heritage Month in Boston

‘Madama Butterfly’ is a poignant American tragedy at Boston Lyric Opera

Special Projects

Boston thrives off the dreams of young people. But can they make it here?

Boston doesn’t work if the T doesn’t work

How the missing become the uncounted

Two Weeks in America

FROM OUR PARTNERS

Opinion, ideas, and commentary

People with Down syndrome deserve access to Alzheimer’s treatment

Chris Christie takes on mission impossible in GOP presidential nomination race

When building bike lanes isn’t enough

After the Vermont flood

Keep Trump on the ballot and let voters decide

My farewell love letter to Boston

Metro

Cystic fibrosis drug Trikafta helps most but not all with the deadly genetic disease

‘Permanent’ jewelry is ‘kind of like part of you’ (yes, you can change your mind)

A breakthrough cystic fibrosis drug gave them the gift of time. But miracles come with complications.

Cystic fibrosis drug Trikafta helps most but not all with the deadly genetic disease

Sports

On 50th anniversary of Billie Jean King’s ‘Battle of the Sexes’ win, a push to honor her in Congress

Why has Massachusetts become a hot spot for Power Five schools to recruit quarterbacks?

Trent Brown, Patriots reportedly agree to revised contract with $2 million added in incentives

Paul Pierce explains how he joined Jayson Tatum’s ‘support system’ during summer workouts

Another uneven night for Tanner Houck and the bullpen costs Red Sox against the Rangers

Bobby Dalbec, 28, is not the same player who was cut at the end of spring training by the Red Sox

Business

‘Permanent’ jewelry is ‘kind of like part of you’ (yes, you can change your mind)

A breakthrough cystic fibrosis drug gave them the gift of time. But miracles come with complications.

Speaker McCarthy faces an almost impossible task trying to unite House GOP and fund the government

Homeowners face rising insurance rates as climate change makes wildfires, storms more common

Shining a spotlight on the lack of diversity backstage

Meet six Mass. leaders from Amplify LatinX's ALX100 list

Five things to do around Boston, Sept. 18-24

Blind date: ‘She grew up in the next town over from me’

metro

Mass. state trooper critically injured in Utah crash recovering in Boston area hospital

Voters pick 2 finalists for mayoral race in Manchester, N.H.

Missing autistic boy from Chelsea found safe at Cambridge recreation center

sports

Buddy Teevens, winningest football coach in Dartmouth history and gridiron innovator, dies at 66
He won five Ivy League championships with the Big Green but more importantly was responsible for advances in player safety.

Why has Massachusetts become a hot spot for Power Five schools to recruit quarterbacks?
Five quarterbacks with Bay State connections have committed to big-time football schools, and they say they helped each other get there.

Witness: Man fatally injured at Gillette was punched twice in head by man in Miami Dolphins jersey
Joey Kilmartin said that after Dale Mooney was punched, he fell backward and did not move even when first responders arrived and provided first aid, including the use of a defibrillator.

Who was Peter Faneuil? A Bostonian, merchant, philanthropist — and slave trader.
Most Bostonians know little about the man for whom Faneuil Hall is named, who enriched himself by trafficking in human beings. Should knowing that history change the way the city remembers him?

Voters pick 2 finalists for mayoral race in Manchester, N.H.
Jay Ruais and Kevin Cavanaugh will face off in the Nov. 7 general election to determine who will lead the largest city in northern New England.

Mass. approves new health and sex ed guidelines for the first time since 1999
The state first started the process of revising sex ed curriculum standards in 2018, and approved the new framework Tuesday after soliciting public comment over the summer.

Boston NWSL team sees this as ‘right moment, right city’ for women’s pro soccer reboot
A hopeful note was sounded as Boston was officially introduced as an expansion franchise in the current 12-team league.

‘Sky is the limit’: Tom Brady explains why he mentors Deion Sanders’s son Shedeur
"I'm always here for him," Brady said. "Because in him I see someone who has a great work ethic, but wants the knowledge too."

Eastern Bank will acquire Cambridge Trust, and sell its insurance division
The move will beef up the Boston-based bank’s wealth management operation while divesting its slower-growing insurance business.

Joe’s Pizza, a New York classic, is now open in Harvard Square until 3 a.m.
Who said local nightlife was dead?

In bid to stop Trump, one group is making different pitch to independents and Democrats: Vote GOP
With a largely drama-less Democratic presidential field, a new super PAC is trying to persuade independent voters in New England — and beyond — to vote in the GOP primary.